DEBONE Collagen Based Bone Grafts

DEBONE Collagen Based Bone Grafts

Collagen-Based Bone Graft Matrix for Regenerative Orthopedic and Dental Applications

Bone tissue loss, whether caused by trauma, tumor resection, infection, or congenital deformities, requires a reliable and bioactive scaffold that can support the regeneration of natural bone. Addressing this critical need in orthopedic, spinal, and dental surgeries, Desu proudly presents DEBONE—an advanced, collagen-based bone graft matrix designed to provide osteoconductivity, biocompatibility, and clinical versatility in a wide variety of bone defect repair cases.

Composed of ultra-pure Type I bovine collagen, DEBONE is enhanced with β-TCP (beta-tricalcium phosphate) to promote bone mineralization and cellular colonization. Its dual-form design—available in both granule and sponge formats—ensures adaptability across diverse clinical scenarios, making it an optimal solution for both small and extensive bone defects.

CE-Certified & ISO Compliant

DEBONE is fully CE-certified, affirming its compliance with strict European Union standards for medical device safety and efficacy. It is manufactured under a certified ISO Quality Management System, ensuring consistency, full traceability, and top-tier quality control in every unit produced.

This adherence to international regulatory frameworks allows DEBONE to be used with confidence in hospitals, clinics, and surgical centers worldwide. All materials are non-toxic, non-immunogenic, and thoroughly tested for sterility and biocompatibility, meeting global medical device standards for implantable products.

Composition and Osteogenic Potential

At the heart of DEBONE lies a highly purified Type I bovine collagen matrix, which serves as a natural scaffold for osteoblast attachment and proliferation. This structure mimics the extracellular matrix of bone, facilitating the in-growth of new blood vessels and bone tissue. With over 95% collagen purity, DEBONE provides a familiar and supportive environment for the body's healing processes.

The incorporation of β-TCP offers both immediate and long-term benefits:

• It contributes to early-stage mineralization, accelerating osteogenesis.
• It is gradually resorbed and replaced by natural bone over time.
• It enhances the scaffold's mechanical integrity and volume stability.

Together, collagen and β-TCP form a powerful osteoconductive platform that does not merely fill space—it promotes the true biological regeneration of bone tissue.

Clinical Advantages

DEBONE offers a broad range of benefits that make it a valuable tool in the surgeon's armamentarium:

• Bioabsorbable: Naturally resorbs as it is replaced by new bone, eliminating the need for secondary removal.
• Biocompatible and safe: Low risk of immune reaction or inflammation.
• High osteoconductivity: Supports bone cell adhesion, migration, and proliferation.
• Available in two physical forms: Granules and sponges for greater surgical flexibility.
• Suitable for multiple surgical fields: Orthopedics, dental, spine, maxillofacial, and trauma.

These features position DEBONE as a trusted alternative to autografts and allografts, minimizing donor site morbidity and offering consistent performance in challenging surgical environments.

Indications for Use

DEBONE is suitable for a wide array of clinical situations involving bone defects and voids, including:

• Bone augmentation prior to implant placement
• Alveolar ridge reconstruction
• Sinus lift procedures
• Periodontal defect filling
• Long bone non-unions and fractures
• Cystic and tumor resection defects
• Spinal fusion and vertebral defect repair
• Trauma-related bone loss

Its adaptability to different defect geometries—combined with a stable structure and ideal absorption profile—makes DEBONE an excellent choice for both primary and adjunctive bone grafting strategies.

Physical Forms and Particle Sizes

DEBONE is manufactured in two distinct forms to accommodate different types of bone defects and surgeon preferences:

• Sponge (SW) – Compressed and porous, ideal for irregular cavities where cohesive, shape-retaining properties are needed.
• Granule (G) – Loose particle form for effective interspace filling and load adaptability.

Each form is available in multiple particle size ranges, including:

1. 0.7–1.5 mm
2. 2–3 mm
3. 3–5 mm
4. 6–7 mm

Product Configurations

DEBONE is available in a variety of volume and particle size combinations, allowing tailored graft selection based on anatomical site, defect size, and surgical technique.

Reference Code	Description
DBN-0715W-5CC	Sponge, 5cc / 0.7–1.5 mm
DBN-23W-5CC	Sponge, 5cc / 2–3 mm
DBNG-5C-D03	Granule, 5cc / 3–5 mm
DBNG-5C-D04	Granule, 5cc / 6–7 mm
DBN-0715W-10CC	Sponge, 10cc / 0.7–1.5 mm
DBN-23W-10CC	Sponge, 10cc / 2–3 mm
DBNG-10C-D03	Granule, 10cc / 3–5 mm
DBNG-10C-D04	Granule, 10cc / 6–7 mm
DBN-0715W-15CC	Sponge, 15cc / 0.7–1.5 mm
DBN-23W-15CC	Sponge, 15cc / 2–3 mm
DBNG-15C-D03	Granule, 15cc / 3–5 mm
DBNG-15C-D04	Granule, 15cc / 6–7 mm
DBN-0715W-20CC	Sponge, 20cc / 0.7–1.5 mm
DBN-23W-20CC	Sponge, 20cc / 2–3 mm
DBNG-20C-D03	Granule, 20cc / 3–5 mm
DBNG-20C-D04	Granule, 20cc / 6–7 mm
DBN-0715W-30CC	Sponge, 30cc / 0.7–1.5 mm
DBN-23W-30CC	Sponge, 30cc / 2–3 mm
DBNG-30C-D03	Granule, 30cc / 3–5 mm
DBNG-30C-D04	Granule, 30cc / 6–7 mm

All units are sterile-packaged, labeled with full traceability data, and ready for immediate surgical use.

DEBONE from Desu represents a new generation of bone grafting materials that merge biological intelligence with surgical precision. By combining high-purity collagen with bioactive β-TCP, DEBONE offers both structural support and a regenerative platform that supports bone repair across a wide range of applications.

Backed by CE certification, ISO compliance, and a reputation for manufacturing excellence, DEBONE provides surgeons with the confidence and performance needed for critical bone regeneration procedures.