PadoBiom®

The patented method for evaluating the gingival sulcus.

PadoBiom® analyzes and evaluates the periodontal microbiome using a patented method based on next-generation sequencing. It tests over 7,000 taxa—including bacteria, fungi, viruses, and parasites—and over 550 oral microorganisms to calculate a dysbiosis index based on more than 120 disease- and health-associated bacteria.

The parameters examined also include 23 relevant antibiotic resistance genes from six classes of antibiotics. The dysbiosis index examines the balance between bacteria for health and disease. In addition, an algorithm checks the risk of progression of periodontitis and can thus assess the expected progression of the disease.

Dysbiosis index and risk of progression

Early detection of dysbiosis and identification of high-risk patients

Assessment symbiosis / dysbiosis

The balance between health- and disease-related bacteria indicates symbiotic or dysbiotic conditions. Only on the basis of this assessment via the dysbiosis index of the oral microbiome a real assessment and the change before clinical symptoms is possible.

Identification of risk of progression

The detection of bacteria in the gingival pocket according to the clinical situation is expectable. Only the identification of deviating microbial loads makes specific therapy possible and identifies high-risk patients who really benefit from adjuvant.

Dysbiosis in the microbiome Antibiotic resistance Optimized antibiotic indication

Detailed evaluation

Key parameters for additional evaluation

Classification of bacteria into 4 categories (donut chart)

Health-associated / Disease-associated / Core species / Other species

Indication of the number of bacterial species detected

Analysis of over 550 bacterial species

List of the most frequent bacteria from dysbiosis index + core species

Main contributing bacteria with a proportion > 0.1%

Periodontitis marker bacteria & Aa serotyping

Detection of pathogenic & highly pathogenic marker bacteria + Aa serotypes

Antibiotic resistance genes

Bacterially induced therapy failure

Antibiotic resistance genes from six antibiotic classes relevant to dental care as indicators of treatment failure.

Recommendation for results

In 3 practice-oriented categories

• Check-up: Regular dental check-up without any need of treatment conclusion
• Prophylaxis: Prophylaxis program with monitoring and regular screening
• Therapy: Periodontal therapy with and without adjuvant (according to risk of progression).

The result recommendations are the essential component that really matters. With PadoBiom® it has been redesigned. Outcome recommendations take the form of classification into one of three practice-based categories, with procedures from the familiar dental treatment spectrum.

This makes it possible for the first time to decide at an early stage which patients belong from the check-up to prophylaxis or even from prophylaxis to therapy. This improves the success of the therapy and even prevents the need for therapy if the diagnosis is made at an early stage.

Advantages for treatment providers

Use PadoBiom® to detect developing periodontitis at an early stage and, in cases of existing disease, to identify high-risk patients and antibiotic resistance.

• Early detection prior to symptom onset
• Patient binding in prophylaxis
• Tool for assessing PDC frequency
• Decision in borderline cases
• Practice-oriented recommendations
• Long-term monitoring
• Differential diagnostics
• Increasing adherence