CERASORB® Bioactive

Product Highlights:

• 99% β-TCP + 4% Na-Mg silicate
• Osteostimulatory & bioactive
• Open, interconnected porosity (mico-, meso- & macropores)
• Complete resorption with vital bone replacement
• 100% synthetic — ZERO risk of disease transmission

What this Trace Element Blend does:

• Magnesium (Mg²⁺): Promotes angiogenesis by activating ion-mediated signaling pathways (e.g., PI3K/Akt), and supports osteogenesis. It also plays a role in immunomodulation, shifting the immune environment toward regeneration and accelerating bone defect healing.
• Sodium (Na⁺): Helps maintain osmotic balance and cellular function; may also raise local pH at the defect site, contributing to potential antibacterial effects.
• Silicate (Si⁴⁺): Stimulates collagen synthesis, bone mineralization, and osteogenic differentiation; supports the simultaneous formation of ACP (amorphous calcium phosphate) and HCA (hydroxycarbonate apatite), accelerating natural bone matrix development.

Advantages of Na-Mg Silicate Doping:

• Enhances surface reactivity for faster bone-bonding
• Stimulates hydroxycarbonate apatite (HCA) layer formation for improved osseointegration
• Boosts osteoblast proliferation and differentiation
• Encourages angiogenesis, essential for sustained tissue regeneration
• Supports controlled resorption aligned with natural bone remodeling rates

Indications:

CERASORB® Bioactive should be used for filling, bridging, and reconstruction of bone defects and augmentation of the atrophied alveolar ridge.

Product Composition:

99% β-TCP + 4% Na-Mg silicate (sodium magnesium silicate addition to β-tricalcium phosphate)