BoneFlo®

BoneFlo® is a patented suction device designed not just to remove, but to preserve and harness biologics from surgical sites during bone regeneration procedures.

What's in the surgical site tissue?

Intraoperatively released tissue has been shown to contain:

1. Mesenchymal stromal cells (MSCs): multipotent cells capable of osteogenic differentiation and superior proliferation compared to bone marrow aspirate.
2. Extracellular vesicles (EVs): biologics messengers enriched with osteogenic microRNAs and proteins, stimulating angiogenesis and bone formation
3. Bone chips and marrow provide a natural osteoconductive framework
4. Growth factors and cytokines, including PDGF, VEGF, TGF-β, and IGF, drive vascularization and osteogenesis.

How does BoneFlo® work?

BoneFlo® integrates a vacuum filter system into routine suctioning. As the surgeon operates, it:

• collects autologous tissue (bone fragments, stromal cells, growth factors, EVs) in a sterile closed system.
• concentrates these elements without clogging, preserving viability.
• enriches scaffold (β-TCP, collagen membrane, polymer foams) intraoperatively by vacuum-assisted impregnation.
• delivers a biologically active graft back into the defect, ready to promote healing.

Clinical Relevance

In conditions like avascular necrosis (AVN) or non-unions, local vascularization and regenerative potential are impaired. BoneFlo® addresses these challenges directly:

• Avoids morbidity at the secondary donor site (iliac crest, RIA).
• Reduces surgical time, bleeding, and infection risk.
• Provides a cost-efficient alternative to recombinant growth factors.
• Creates grafts that are alive, bioactive, and osteoinductive at the time of implantation.

Why does this matter to the surgeons?

BoneFlo® allows surgeons to:

• Maximize patient-derived biology.
• Improve scaffold performance with viable cells and growth factors.
• Integrates scaffold performance with cells and growth factors.
• Integrates seamlessly into the routine workflow
• Deliver bone regeneration support even in patients with limited healing potential (elderly, smokers, metabolic disorders).

Bone healing is not only mechanical but also biological. BoneFlo® redefines suction as a therapeutic ally, giving surgeons the ability to capture and reuse the body's own regenerative power intraoperatively.