NovoMatrix Soft tissue regeneration

Product Description

NovoMatrix is an acellular dermal matrix derived from porcine tissue. In surgical application, the tear-resistant and easy-to-handle matrix is an excellent alternative to autologous connective tissue grafts (CTG). There is no need for an intraoral surgical donor site, which reduces morbidity for the patient.

Owing to the manufacturing process, the matrix is free of donor cells. At the same time, the structure of the source tissue remains virtually unchanged, thus supporting the ingrowth of cells and micro-vessels. Proprietary tissue processing enables optimal cell repopulation and revascularization through gentle preparation, resulting in esthetic soft tissue regeneration.

NovoMatrix is supplied pre-hydrated in a patented aqueous phosphate-buffered solution containing matrix stabilizers and can therefore be used promptly without requiring extensive rehydration.

Indications

• Increase in attached tissue around teeth and implants
• Reconstruction of the alveolar ridge for prosthetic restoration
• Guided tissue regeneration in recession defects for root coverage

Key Features

• The LifeCell tissue preparation process results in rapid revascularization.
• Consistent tissue thickness at all times
• Pre-hydrated – ready-to-use out of the package following a 2-minute soak in sterile saline or lactated Ringer's solution
• Storage at -8° C to +30° C

Maintenance of graft integrity is essential to achieving successful biological outcomes. NovoMatrix is minimally manipulated and processed gently to ensure it retains components critical to maintaining the biochemical and biomechanical integrity of the tissue.

Benefits

• Shorter surgery time - The ready-to-use collagen matrix shortens surgery time by eliminating the need for a second donor site.

• Lower patient morbidity - Avoiding a donor site on the palate eliminates the post-operative pain associated with a second procedure.

• Excellent tissue integration - The application of NovoMatrix supports rapid revascularization, cellular repopulation and minimal inflammatory reactions.

• Natural tissue and color structure - The application of NovoMatrix demonstrates irritation-free healing and very good adaptation of the color and tissue structure to the natural surrounding tissue.

• Rapid and complication-free healing of soft tissue - The application of NovoMatrix supports a positive immunological reaction as well as tissue integration and regeneration.

Manufacturing Process

The LifeCell tissue preparation process includes:

• Tissue selection: Manufactured from targeted porcine tissue for desired mechanical and handling properties.
• Dermis isolation: Non-chemical based method that removes all non-dermal tissue retaining the structural integrity of the matrix.
• Microbial neutralization: Proprietary process removes 99.9% of the pathogens, enabling a more gentle preparation process.
• Decellularization enzyme treatment: Maintains the natural collagen structure while extracting the porcine alpha-gal antigen, as well as the cell and DNA components to minimize the xenogenic immune response.
• Matrix preservation: The proprietary preparation process stabilizes the key matrix proteins as well as protecting the integrity of the acellular dermal matrix, thus providing a platform for tissue regeneration.
• Sterilization: Optimized sterilization process to preserve the natural tissue structure, thus retaining the regenerative properties of the acellular dermal matrix.

An intact acellular dermal matrix derived from porcine tissue that retains the biochemical components that support a positive immunological response and regeneration.

NovoMatrix shows a histological structure comparable to human tissue.